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Published articles

Variability in the management and outcomes of extremely preterm births across five European countries: a population-based cohort study
Lucy K Smith, Beatrice Blondel, Patrick Van Reempts, Elizabeth S Draper, Bradley N Manktelow, Henrique Barros, Marina Cuttini, Jennifer Zeitlin, for the EPICE Research Group
Arch Dis Child Fetal Neonatal Ed. (2017)

As a result of improved antenatal and neonatal care, survival has increased for infants born at the limits of viability, however not without risk of severe morbidities. Counselling parents and making decisions about treatments for these infants is difficult, as survival rates vary widely. The aim was to explore international variations in the management and survival of extremely low gestational age and birthweight births in the EPICE regions of Belgium, France, Italy, Portugal and the UK.

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Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population-based studies in ten European regions
M Bonet, M Cuttini, A Piedvache, EM Boyle, PH Jarreau, L Kollée, RF Maier, DWA Milligan, P Van Reempts, T Weber, H Barros, J Gadzinowki, ES Draper, J Zeitlin, the MOSAIC and EPICE research groups
BJOG (2017)

Although the survival of infants born extremely preterm (before 27 weeks of gestation) has improved, the survival rates vary greatly across countries. This may reflect different policies for active treatment of these infants. The objective was to study mortality and morbidity in extremely preterm infants in relation to changes in maternity and neonatal unit policies in 10 European regions between 2003 and 2012, using data from the MOSAIC and EPICE cohorts.

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Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals With Survival and Morbidity Among Very Preterm Infants: Results From the EPICE Cohort
Mikael Norman, Aurelie Piedvache, Klaus Børch, Lene Drasbek Huusom, Anna-Karin Edstedt Bonamy, Elizabeth A. Howell, Pierre-Henri Jarreau, Rolf F. Maier, Ole Pryds, Liis Toome, Heili Varendi, Tom Weber, Emilija Wilson, Arno Van Heijst, Marina Cuttini, Jan Mazela, Henrique Barros, Patrick Van Reempts, Elizabeth S. Draper, Jennifer Zeitlin, for the Effective Perinatal Intensive Care in Europe (EPICE) Research Group
JAMA Pediatr. (2017)

Antenatal corticosteroids (ANS) are administered to pregnant women at risk of delivery before 34 weeks of gestation, in order to reduce morbidity and mortality in their infants. The administration-to-birth intervals of ANS varies, and it is not known how close to delivery ANS administration is efficient. The aim was to explore the association between the time from first ANS injection to delivery and survival and morbidity among 4594 singleton very preterm infants in all 19 of the EPICE regions.

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Variation in term birth weight across European countries affects the prevalence of small for gestational age among very preterm infants
Jennifer Zeitlin, Anna-Karin Edstedt Bonamy, Aurelie Piedvache, Marina Cuttini, Henrique Barros, Patrick Van Reempts, Jan Mazela, Pierre-Henri Jarreau, Ludwig Gortner, Elizabeth S. Draper, Rolf F. Maier and the EPICE Research Group
Acta Paediatr. (2017)

Intrauterine growth references are used for assessing the growth of very preterm (VPT) infants; a birth weight below the 10th percentile is considered to be small for gestational age (SGA). The aim was to assess the prevalence of infants classified as SGA using two different intrauterine growth references - country-specific and common European references - in 7766 VPT live births in the EPICE cohort.

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Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort
Jennifer Zeitlin, Bradley N Manktelow, Aurelie Piedvache, Marina Cuttini, Elaine Boyle, Arno van Heijst, Janusz Gadzinowski, Patrick Van Reempts, Lene Huusom, Tom Weber, Stephan Schmidt, Henrique Barros, Dominico Dillalo, Liis Toome,  Mikael Norman, Beatrice Blondel, Mercedes Bonet, Elisabeth S Draper, Rolf F Maier, and the EPICE Research Group
BMJ (2016)

Evidence-based practices are shown to improve health outcomes in children born preterm in randomised trials, but their use and impact in routine clinical practice remain poorly understood. We studied the implementation of high-evidence practices to assess whether they constitute a lever for reducing mortality and morbidity in children born preterm.

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